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No specific labeling by NbLumSyt1, fused to a GFP-tag, was observed after incubating neurons from Syt1 knockout (KO) mice 18 , confirming specificity as also further confirmed by immunoprecipitation experiments, in which endogenous Syt1 was enriched from wildtype (WT) but not from Syt1-KO brain extracts ( Fig

Anhedonia (loss of pleasure), induced by ketamine 30 mg/kg reducing sucrose preference over 72 hours, was counteracted by BPC-157 with sustained benefit across multiple days

And the treatment discontinuation rate due to adverse events rose to approximately 6%, still reasonable but six times higher than cagrilintide monotherapy